Post Doc Disc and Cartilage Biology

The AO is a medically-guided, not-for-profit organization, a global network of surgeons, and the world's leading education, innovation, and research organization specializing in the surgical treatment of trauma and musculoskeletal disorders. We have a global network of over 385,000 health care professionals. Each year we offer over 830 educational events around the world, supported by nearly 9,000 faculty members and attended by over 58,000 participants. We have around 18,500 surgeon members working in the fields of trauma, spine, craniomaxillofacial, veterinary, and reconstructive surgery. For more information, visit: https://www.aofoundation.org/
 

The mission of the AO Research Institute (ARI) is excellence in applied Preclinical Research and Development within trauma and disorders of the musculoskeletal system and translation of this knowledge to achieve more effective patient care worldwide. The ARI contributes high quality applied Preclinical Research and Development (exploratory and translational) focused towards clinical applications/solutions as well as investigates and improves the performance of surgical procedures, devices and substances. It fosters a close relationship with the AO medical community, academic societies, and universities and provides a research environment and support for AO clinicians.

Employment Type:  Temporary
Part-time percentage:  100%
This position is located in: 

Davos Platz, CH

Experience level:  Professional Newcomers
Please send us your application documents in:  English

In this role you are required to

The candidate will work within an interdisciplinary team to contribute to the overall aim of the SINPAIN project. Towards this aim the candidate will establish 3D OA model in bi-layered constructs for chondrocytes, pericytes, endothelial cells co-culture, and chondrocytes, sensory neurons co-culture. The transfection efficiency and treatment efficacy of RNA functionalized nanotherapeutics will be tested for inhibition of chondrocytes fibrosis and neuronal sprouting under inflammatory OA condition. A unique bioreactor system developed at the AO Research Institute Davos will be used, mimicking the physiological biomechanical environment within the knee joint. The main objective is to assess the efficacy of the novel gene therapies in the 3D OA model within the bioreactor.

To master this role you have

Postdoctoral Position at the AO Research Institute Davos

The current job opportunity is supported by the HORIZON EUROPE project entitled “A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis” (SINPAIN). The consortium addresses an unmet clinical need and societal problem that represents the leading cause of disability and morbidity worldwide, namely osteoarthritis (OA). Taking advantage of the explosion of RNA technologies in the last years, the SINPAIN consortium aims to develop a pipeline of siRNA-based therapy to reach a successful management of inflammation and innervation for the treatment of knee OA. In parallel, large effort will focus on understanding the pathological mechanisms of OA. To validate efficacy in relevant potency assays, 3D coculture models will be developed with human cells and tested in unique bioreactors mimicking joint environment and biomechanics. The products of SINPAIN will be validated in vivo in a relevant OA animal model. Based on all the data obtained during the project, a decision-making tool based on machine learning will be validated to offer patients a personalized therapy.
The post-doctoral fellow will be working in the Disc and Cartilage Biology Focus Area of the Regenerative Orthopaedics Program at the AO Research Institute Davos (ARI), Switzerland. There will be a close collaboration with the other project partners, who are based in Spain, France, Germany, Portugal, Italy, UK, and the USA.

Expertise
PhD in biology, biomedical engineering or related field, with academic excellence in research, demonstrated by an outstanding publication record. Solid grounding in cell/tissue culture, cellular and molecular biology, biochemical and molecular biological analysis is required. Integrative thinking, management of complex projects, and teaching experience are considered a plus.
The ideal applicant is enthusiastic, creative, with excellent communication skills and can work in a multidisciplinary team. You will also be expected to supervise and teach students and fellows of the research team.

We offer

  • An interesting and varied job in an exciting and innovative organization
  • The opportunity to be part of a highly committed international team
  • Modern infrastructure
  • Employment conditions which match the requirements and offer a high degree of flexibility regarding working hours and location

If you meet the requirements of this challenging opportunity, please submit your complete online application (motivation letter, CV, recent photograph, certificates, reference letters, etc) through our online application system.

Date of publication:  May 30, 2022